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BRADYKININ STORM: COVID-19

BRADYKININ STORM: COVID-19

Context

Samples of patients with the Covid-19 infection have shown a phenomenon called a ‘bradykinin storm’.

What is the bradykinin?

  • Bradykinin is a compound that is related to pain sensation and lowering blood pressure in the human body.

Recent finding

  • As per the researchers, SARS-CoV-2 uses a human enzyme called ACE2 like a ‘Trojan Horse’ to sneak into the cells of its host.
  • ACE2 lowers blood pressure in the human body and it  works against another enzyme known as ACE.
  • Researchers found that the virus caused the levels of ACE to fall in the lungs, and consequently pushed up the levels of ACE2, which increases the levels of the molecule bradykinin in the cells, causing a bradykinin storm, which causes the blood vessels to expand and become leaky, leading to swelling of the surrounding tissue.

Effects of Bradykinin storm

  • With storms, there is a leakage of fluid into the lungs which is combined with the excess hyaluronic acid that results in a Jelly-like substance, which prevents oxygen uptake and carbon dioxide in the lungs of severely affected COVID-19 patients.
  • This rapid accumulation of fluid in the lungs of patients sometimes makes the most intensive care, including ventilators useless.

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