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Cancer drug to destroy tumours from inside shows promising results

Cancer drug to destroy tumours from inside shows promising results

Researchers from the Institute of Cancer Research in the UK have discovered a new innovative drug called tisotumab vedotin (TV).

The results of this study were published in The Lancet Oncology.

What is TV?

TV releases a toxic substance to kill cancer cells from within.

TV is made up of a toxic drug attached to the tail end of an antibody.

It is designed to seek out a receptor called 'tissue factor' present at high levels on the surface of many cancer cells and linked with worse survival. Binding to tissue factor draws the drug inside cancer cells, where it can kill them from within.

The researchers led a global clinical trial of nearly 150 patients with a variety of cancer types who had stopped responding to standard treatments. They found that a significant minority of cancer patients responded to the drug, with their tumours either shrinking or stopping growing.

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